Activation of the fibrin stabilizing factor of plasma by thrombin

作者: L. Lorand , K. Konishi

DOI: 10.1016/0003-9861(64)90235-8

关键词:

摘要: Abstract Two new reactions in the final stages of blood coagulation that involve fibrin stabilizing factor plasma are described. The is first activated by thrombin presence calcium ions. thrombin-activated form can then exert its polymerizing effect on and lead to formation a clot which insoluble 1% monochloroacetic acid thus resembles normal clot. Calcium ions essential also for polymerization reaction.

参考文章(21)
Sol Sherry, Walter Troll, The action of thrombin on synthetic substrates. Journal of Biological Chemistry. ,vol. 208, pp. 95- 105 ,(1954) , 10.1016/S0021-9258(18)65627-3
L. Lorand, Ann Jacobsen, Studies on the polymerization of fibrin; the role of the globulin: fibrin-stabilizing factor. Journal of Biological Chemistry. ,vol. 230, pp. 421- 434 ,(1958) , 10.1016/S0021-9258(18)70577-2
Ariel G. Loewy, Katy Dunathan, Robert Kriel, Howard L. Wolfinger, Fibrinase. I. Purification of substrate and enzyme. Journal of Biological Chemistry. ,vol. 236, pp. 2625- 2633 ,(1961) , 10.1016/S0021-9258(19)61711-4
L. LORAND, K. KONISHI, A. JACOBSEN, Transpeptidation mechanism in blood clotting. Nature. ,vol. 194, pp. 1148- 1149 ,(1962) , 10.1038/1941148A0
John D. Ferry, Meredith Miller, Sidney Shulman, The conversion of fibrinogen to fibrin. VII. Rigidity and stress relaxation of fibrin clots; effect of calcium Archives of Biochemistry and Biophysics. ,vol. 34, pp. 424- 436 ,(1951) , 10.1016/0003-9861(51)90021-5
Ariel G. Loewy, Carlo Veneziale, Marc Forman, Purification of the factor involved in the formation of urea-insoluble fibrin. Biochimica et Biophysica Acta. ,vol. 26, pp. 670- 671 ,(1957) , 10.1016/0006-3002(57)90133-6
T.H. Donnelly, M. Laskowski, N. Notley, H.A. Scheraga, Equilibria in the fibrinogen-fibrin conversion. II. Reversibility of the polymerization steps Archives of Biochemistry and Biophysics. ,vol. 56, pp. 369- 387 ,(1955) , 10.1016/0003-9861(55)90258-7
Koloman Laki, The polymerization of proteins; the action of thrombin on fibrinogen. Archives of Biochemistry and Biophysics. ,vol. 32, pp. 317- 324 ,(1951) , 10.1016/0003-9861(51)90277-9
N. Chandrasekhar, L. Warren, A.J. Osbahr, K. Laki, Role of sialic acid in fibrinogen. Biochimica et Biophysica Acta. ,vol. 63, pp. 337- 339 ,(1962) , 10.1016/0006-3002(62)90688-1