(5Z)-7-Oxozeaenol: A novel and potent resorcylic acid lactone kinase inhibitor with a cis-enone Michael acceptor.

作者: George A. Ellestad

DOI: 10.1002/CHIR.23040

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参考文章(33)
ANNIE ZHAO, SEOK H. LEE, MARINA MOIENA, ROSALIND G. JENKINS, DENIS R. PATRICK, HANS E. HUBER, MICHAEL A. GOETZ, OTTO D. HENSENS, DEBORAH L. ZINK, DOLORES VILELLA, ANNE W. DOMBROWSKI, RUSSELL B. LINGHAM, LEEYUAN HUANG, Resorcylic Acid Lactones: Naturally Occurring Potent and Selective Inhibitors of MEK The Journal of Antibiotics. ,vol. 52, pp. 1086- 1094 ,(1999) , 10.7164/ANTIBIOTICS.52.1086
Tsutomu AGATSUMA, Akira TAKAHASHI, Chizuko KABUTO, Shigeo NOZOE, Revised Structure and Stereochemistry of Hypothemycin Chemical & Pharmaceutical Bulletin. ,vol. 41, pp. 373- 375 ,(1993) , 10.1248/CPB.41.373
Lara Fakhouri, Tamam El-Elimat, Dow P. Hurst, Patricia H. Reggio, Cedric J. Pearce, Nicholas H. Oberlies, Mitchell P. Croatt, Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues. Bioorganic & Medicinal Chemistry. ,vol. 23, pp. 6993- 6999 ,(2015) , 10.1016/J.BMC.2015.09.037
H. Du, T. Matsushima, M. Spyvee, M. Goto, H. Shirota, F. Gusovsky, K. Chiba, M. Kotake, N. Yoneda, Y. Eguchi, L. DiPietro, J.-C. Harmange, S. Gilbert, X.-Y. Li, H. Davis, Y. Jiang, Z. Zhang, R. Pelletier, N. Wong, H. Sakurai, H. Yang, H. Ito-Igarashi, A. Kimura, Y. Kuboi, Y. Mizui, I. Tanaka, M. Ikemori-Kawada, Y. Kawakami, A. Inoue, T. Kawai, Y. Kishi, Y. Wang, Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead Bioorganic & Medicinal Chemistry Letters. ,vol. 19, pp. 6196- 6199 ,(2009) , 10.1016/J.BMCL.2009.08.096
MARTIN STOB, R. S. BALDWIN, JOHN TUITE, F. N. ANDREWS, K. G. GILLETTE, Isolation of an anabolic, uterotrophic compound from corn infected with Gibberella zeae. Nature. ,vol. 196, pp. 1318- 1318 ,(1962) , 10.1038/1961318A0
Jun Ninomiya-Tsuji, Taisuke Kajino, Koichiro Ono, Toshihiko Ohtomo, Masahiko Matsumoto, Masashi Shiina, Masahiko Mihara, Masayuki Tsuchiya, Kunihiro Matsumoto, A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase Journal of Biological Chemistry. ,vol. 278, pp. 18485- 18490 ,(2003) , 10.1074/JBC.M207453200
Yongchun Shen, Roch Boivin, Naoki Yoneda, Hong Du, Shawn Schiller, Tomohiro Matsushima, Masaki Goto, Hiroshi Shirota, Fabian Gusovsky, Charles Lemelin, Yimin Jiang, Zhiyi Zhang, Robert Pelletier, Megumi Ikemori-Kawada, Yoshiyuki Kawakami, Atsushi Inoue, Matthew Schnaderbeck, Yuan Wang, Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 3155- 3157 ,(2010) , 10.1016/J.BMCL.2010.03.087
Megumi Ikemori-Kawada, Atsushi Inoue, Masaki Goto, Yuan John Wang, Yoshiyuki Kawakami, Docking simulation study and kinase selectivity of f152A1 and its analogs. Journal of Chemical Information and Modeling. ,vol. 52, pp. 2059- 2068 ,(2012) , 10.1021/CI300135G
Pierre-Yves Dakas, Sofia Barluenga, Frank Totzke, Ute Zirrgiebel, Nicolas Winssinger, Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors. Angewandte Chemie. ,vol. 46, pp. 6899- 6902 ,(2007) , 10.1002/ANIE.200702406