A new MALDI-TOF-based assay for monitoring JAK2 V617F mutation level in patients undergoing allogeneic stem cell transplantation (allo SCT) for classic myeloproliferative disorders (MPD).
作者： Avichai Shimoni , Asaf Vivante , Luba Trakhtenbrot , Gideon Rechavi , Ninette Amariglio
DOI: 10.1016/J.LEUKRES.2007.07.003
关键词:
摘要: JAK2 V617F mutation is found in a high proportion of MPD patients. We developed quantitative assay for the detection and demonstrated its clinical utility patients who underwent SCT. Sixty percent were positive prior to SCT (mean levels 74%, range 16-98%). After procedure, progressively decreased correlation with donor-recipient chimerism status (r=0.97, p<0.001). At median follow up 16 months (range 2-58), 9/15 are alive CR. The reached 0% all surviving
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