Methodological Considerations for Optimizing and Validating Behavioral Assays.

摘要: Preclinical animal models are indispensable tools for translational research which behavioral characterization and phenotyping essential to testing hypotheses evaluating the potential of novel therapeutic agents treat diseases. The methods employed comprehensive pharmacological experiments complex should be conducted exclusively by trained technicians with demonstrated proficiency. ultimate goal is identify disease-relevant endpoints that robust, reliable, reproducible, can evaluate disease. intent present article provide a pragmatic outline establishing optimizing assays batteries, ensuring data reliable such they reproduced within across laboratories and, more importantly, translatable clinic. © 2016 John Wiley & Sons, Inc.