Preliminary results of treatment of eyes with high-risk prethreshold retinopathy of prematurity in the early treatment for retinopathy of prematurity randomized trial.

摘要: Objective: To determine whether earlier treatment using ablation of the avascular retina in high-risk prethreshold retinopathy prematurity (ROP) results improved grating visual acuity and retinal structural outcomes compared with conventional treatment. Methods: Infants bilateral ROP (n=317) had one eye randomized to early fellow managed conventionally (control eye). In asymmetric cases (n=84), was or management. High risk determined a model based on Multicenter Trial Cryotherapy for Retinopathy Prematurity natural history cohort. At corrected age 9 months, assessed by masked testers Teller card procedure. ages 6 eyes were examined outcome. Outcomes 2 groups X analysis, combining data cases. Results: Grating showed reduction unfavorable treatment, from 19.5% 14.5% (P=.01). Unfavorable reduced 15.6% 9.1% (P<.001) at months. Further analysis supported ablative therapy type 1 ROP, defined as zone I, any stage plus disease (a degree dilation tortuosity posterior blood vessels meeting exceeding that standard photograph); 3 without disease; II, disease. The wait-and-watch approach 1, These should be considered only if they progress threshold ROP. Conclusions: Early significantly clinically important degree. Additional analyses led modified recommendations use peripheral Long-term follow-up is being conducted learn benefits noted first year after birth will persist into childhood.