Spectroscopic studies of methylglyoxal in water and dimethylsulfoxide
作者： Ina Nemet , Dražen Vikić-Topić , Lidija Varga-Defterdarović
DOI: 10.1016/J.BIOORG.2004.05.008
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摘要: Abstract Methylglyoxal is a highly reactive dicarbonyl compound, which reacts in vivo with biological macromolecules and thereby affects their structure function. These changes are associated complications during aging, diabetes Alzheimer’s disease as well growth inhibition different tumors. Many enzymes involved the metabolism of methylglyoxal, but its true physiological role chemical properties still obscure. In this study it was shown that freeze-drying aqueous solutions, polymerizes into small polymeric structures stable organic media such dimethylsulfoxide. When re-exposed to water, polymers immediately transformed monomeric mono- dihydrate forms methylglyoxal. By NMR UV spectroscopy, solvent, temperature, amount available water strongly influence equilibrium methylglyoxal change reactivity. 1H 13C spectroscopy were used determine oligomeric
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