Response and Cardiac Toxicity of Trastuzumab Given in Conjunction with Weekly Paclitaxel After Doxorubicin/Cyclophosphamide
作者： Hanna Kelly , Gretchen Kimmick , E. Claire Dees , Frances Collichio , Lisa Gatti
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摘要: Abstract Background Adjuvant trastuzumab improves relapse-free survival in HER2-overexpressing breast cancer but is associated with cardiac toxicity. This phase II study was undertaken to determine the neoadjuvant clinical and pathologic response rate acute chronic toxicity of given weekly paclitaxel after AC (doxorubicin/cyclophosphamide). Patients Methods Fifty-two women newly diagnosed, stage II-IV, received for 4 cycles, followed by TP (paclitaxel/trastuzumab) 12 weeks, neoadjuvantly or adjuvantly, 40 weeks adjuvant trastuzumab. Results Congestive heart failure occurred 4% patients (95% confidence interval [CI], 0.5%-13.2%). Asymptomatic left ventricular ejection fraction (LVEF) decreases P Conclusion In this study, AC-TP regimen resulted a high moderate rate, although asymptomatic systolic dysfunction common, most severe recovered over time.
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