Treatment of 71 adult acute lymphoblastic leukemia

摘要: From 1975 to 1989, 71 acute lymphoblastic leukemia patients aged 15 81 years (median 46 years) were treated at Jichi Medical School. Fifty-eight (81.7%) achieved complete remission (CR). Median CR duration was 219 days, and the probability of being in continuous 3 8.9%. survival 462 probabilities alive 5 19.8% 7.3%, respectively. The new regimen introduced from 1987 consisted induction with L-asparaginase, daunomycin, vincristine prednisolone, followed by intensive consolidation maintenance. However, treatment failed improve outcome. factor unfavorable for achieving early after first-line presence myeloid antigen, that final second-line advanced age. factors high leukocyte count late CR. Those age elevated blood urea nitrogen. Further improvement design protocols which include use several cytokines autologous bone marrow transplantation may result prolonged disease-free survival.