Identification of potential key genes for SARS-CoV-2 infected human bronchial organoids based on bioinformatics analysis
作者： Hanming Gu , Gongsheng Yuan
DOI: 10.1101/2020.08.18.256735
关键词:
摘要: Abstract There is an urgent need to understand the pathogenesis of severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) that leads COVID-19 and failure. Our study discover differentially expressed genes (DEGs) biological signaling pathways by using a bioinformatics approach elucidate their potential pathogenesis. The gene expression profiles GSE150819 datasets were originally produced Illumina NextSeq 500 (Homo sapiens). KEGG (Kyoto Encyclopedia Genes Genomes) GO (Gene Ontology) utilized identify functional categories significant pathways. results suggested Cytokine-cytokine receptor interaction, P53 pathway, Apoptosis are main in SARS-CoV-2 infected human bronchial organoids (hBOs). Furthermore, NFKBIA, C3, CCL20 may be key hBOs. Therefore, our provides further insights into therapy COVID-19.
sci-hub.st 参考文章(30)
Giuseppe Russo, Charles Zegar, Antonio Giordano, Advantages and Limitations of Microarray Technology in Human Cancer Oncogene. ,vol. 22, pp. 6497- 6507 ,(2003) , 10.1038/SJ.ONC.1206865
M. Kanehisa, S. Goto, Y. Sato, M. Furumichi, M. Tanabe, KEGG for integration and interpretation of large-scale molecular data sets Nucleic Acids Research. ,vol. 40, pp. 109- 114 ,(2012) , 10.1093/NAR/GKR988
Rachael M. Liesman, Ursula J. Buchholz, Cindy L. Luongo, Lijuan Yang, Alan D. Proia, John P. DeVincenzo, Peter L. Collins, Raymond J. Pickles, RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction Journal of Clinical Investigation. ,vol. 124, pp. 2219- 2233 ,(2014) , 10.1172/JCI72948
Wei-Hong Long, Hua-Sheng Xiao, Xiao-Mei Gu, Qing-Hua Zhang, Hong-Jun Yang, Guo-Ping Zhao, Jian-Hua Liu, A universal microarray for detection of SARS coronavirus. Journal of Virological Methods. ,vol. 121, pp. 57- 63 ,(2004) , 10.1016/J.JVIROMET.2004.06.016
KF To, Anthony WI Lo, Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). The Journal of Pathology. ,vol. 203, pp. 740- 743 ,(2004) , 10.1002/PATH.1597
Keiji Kuba, Yumiko Imai, Shuan Rao, Hong Gao, Feng Guo, Bin Guan, Yi Huan, Peng Yang, Yanli Zhang, Wei Deng, Linlin Bao, Binlin Zhang, Guang Liu, Zhong Wang, Mark Chappell, Yanxin Liu, Dexian Zheng, Andreas Leibbrandt, Teiji Wada, Arthur S Slutsky, Depei Liu, Chuan Qin, Chengyu Jiang, Josef M Penninger, A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury Nature Medicine. ,vol. 11, pp. 875- 879 ,(2005) , 10.1038/NM1267
S Asburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel‐Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock, Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genetics. ,vol. 25, pp. 25- 29 ,(2000) , 10.1038/75556
T. Lawrence, The Nuclear Factor NF-κB Pathway in Inflammation Cold Spring Harbor Perspectives in Biology. ,vol. 1, ,(2009) , 10.1101/CSHPERSPECT.A001651
Koji Taniguchi, Michael Karin, NF-κB, inflammation, immunity and cancer: coming of age Nature Reviews Immunology. ,vol. 18, pp. 309- 324 ,(2018) , 10.1038/NRI.2017.142
G. Yuan, L. Xu, T. Cai, B. Hua, N. Sun, Z. Yan, C. Lu, R. Qian, Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB. Osteoarthritis and Cartilage. ,vol. 27, pp. 922- 931 ,(2019) , 10.1016/J.JOCA.2019.01.012