Estudo genético-epidemiológico da hemoglobina S em uma população do Sudeste do Brasil

摘要: Sickle cell anemia, the clinical expression of individuals homozygous for hemoglobin S gene, is most frequent hereditary disease in Brazil. Nevertheless, a genetic-epidemiological approach rarely used Brazilian studies related to this alteration. In present study, using specific computer program, data from 817 (513 males and 304 females) non-consanguineous heterozygous gene were studied. The participants, with ages varying 18 65 years old, live region Campinas, Southeastern Caucasoid, Negroid native Indian genomic backgrounds sample evaluated by study allelic frequencies ABO blood group system compared those observed general population same city. Data analysis showed that: 52% carriers had African ancestry as shown their phenotypes that 36% subjects came North-eastern Brazil, state Bahia (15%). This internal migration tends decrease proportion Bantu (wild) haplotype increasing Benin (milder). Negroes 45%, Caucasians 41%, Indians 14%. constitution significantly different city greater lower frequency Caucasians. Migration northeastern miscegenation have altered profile Campinas.