Inhibition of long-term potentiation in the schaffer-CA1 pathway by repetitive high-intensity sound stimulation

摘要: High-intensity sound can induce seizures in susceptible animals. After repeated acoustic stimuli changes behavioural seizure repertoire and epileptic EEG activity might be seen recruited limbic forebrain structures, a phenomenon known as audiogenic kindling. It is postulated that kindling produce synaptic plasticity events leading to the spread of epileptogenic system. In order test this hypothesis, we investigated if long-term potentiation (LTP) hippocampal Schaffer-CA1 synapses spatial navigation memory are altered by high-intensity stimulation (HISS) protocol, consisting one-minute 120 dB broadband noise applied twice day for 10 days, normal Wistar rats seizure-prone (Wistar Audiogenic Rats - WARs). HISS all WARs exhibited midbrain 50% these animals developed recruitment, while only 26% presented none them had recruitment. naive animals, LTP CA1 neurons was induced 50- or 100-Hz high-frequency Schaffer fibres slices from both WAR similarly. Surprisingly, suppressed did not present any seizure, inhibited with seizures. However no effect on WARs. Interestingly alter strains. These findings show prevent rats, without affecting memory. This hippocampi link between auditory seems disrupted which could relevant susceptibility strain.