Psychiatric Manifestations of Cushing’s Syndrome

摘要: The constellation of clinical signs and symptoms that we now call “Cushing’s syndrome” was first described by Cushing in 1932. Cushing’s syndrome results from chronic exposure to excessive concentrations glucocorticoids. physical features include weight gain, central obesity (i.e., accumulation adipose tissue the facial, nuchal, truncal girdle areas), facial plethora, hirsutism, cutaneous striae, muscle wasting, weakness, osteoporosis. Other common manifestations hypercortisolemia hypertension, glucose intolerance or diabetes mellitus, impotence testicular atrophy, amenorrhea, mild erythrocytosis, lymphopenia, eosinopenia frequent fungal infections. can be divided into two major categories, each which has causes. ACTH-dependent caused ACTH secretion a pituitary microadenoma (referred as disease”) non-pituitary tumor (“ectopic syndrome”), usually small cell carcinoma lung bronchial, thymic pancreatic carcinoid tumor, together account for 75% all cases. ACTH-independent is adrenocortical tumors secrete cortisol autonomously administration pharmacologic doses synthetic