Bronchioloalveolar Carcinoma (Lepidic Growth) Component Is a More Useful Prognostic Factor than Lymph Node Metastasis

摘要: Introduction: Although many factors predictive of patient survival have been reported for lung cancer, no comparative studies attempted to determine those that are most significant practical medicine. Methods: We conducted a retrospective review 139 patients who underwent complete resection adenocarcinomas less than 2 cm in diameter between 1993 and 2000 at the National Cancer Center Hospital (Tokyo, Japan). The MIB-1 labeling index (LI), immunohistochemical staining carcinoembryonic antigen (CEA), p53, p27, epidermal growth factor receptor (EGFR), phosphorylated-EGFR (pEGFR), Cox-2, neuronatin, γH2AX, thyroid transcription factor-1 (TTF-1), prevalence micropapillary pattern, ratio bronchioloalveolar cell carcinoma (BAC) or lepidic (LG) component were determined, their significance as prognostic adenocarcinoma was compared. Results: Univariate analysis showed lymph node metastasis (p-N status), BAC/LG component, vascular invasion (p-V LI, pEGFR, CEA prognostically status: p Conclusion: In comparison with other histopathologic factors, is independently reliably small lung, and, particular, major histologic subtype (adenocarcinoma mixed BAC/LG), more metastasis.