Laryngopharyngeal reflux disease: clinical presentation, diagnosis and therapeutic challenges in 2018.

摘要: PURPOSE OF REVIEW To review the recent literature on presentation, diagnosis and treatment of laryngopharyngeal reflux. RECENT FINDINGS Patients with reflux have a higher risk for gastroesophageal respiratory-related diseases. Many symptoms findings are underestimated, contributing to inconclusive results many therapeutic trials. Additionally, little significance is given nonacid mixed refluxates, although significant prevalence. The association between symptoms, signs, impedance-pH studies pepsin detection could be most accurate way clear diagnosis. 'Reflux profiling' also important administration personalized based diet, proton pump inhibitors, alginate, magaldrate other second-line drugs. There only handful focusing addition alginate or reflux, their contribution has extensively been demonstrated. SUMMARY Diagnosis remains controversial despite improvement in impedance availability daily practice. With exhibiting prevalence refluxes, inhibitors should considered. Future needed assess these new schemes moderate severe