Immunogenetic markers as probes for polymorphism, gene regulation and gene transfer in man--the Gm system in perspective.

摘要: The genetic markers of immunoglobulins (Ig) demonstrable by immunological methods have shown their usefulness as probes. study these allotypes originally proved that Ig production is under conventional control and also established allelic exclusion valid for the key molecules immune response. codons responsible G1m(a) marker position in human genome are precisely known. This knowledge implies Gm typing may be used a convenient reliable means following fate IgG constant gene segments. Anti-Gm's common rheumatoid arthritis. They appear early disease persist throughout life. stimulus appearance has not yet been established. anti-Gm's allegedly autoimmune arthritis commonly apparently paradoxically specific products other persons. Another apparent paradox brought to light allotype research occasional non-nominal contradiction Mendelian laws. It proposed plausible explanation two paradoxes transfer between individuals with viral vectors. Reasons this proposal some possible consequences polymorphic species delineated. Immunogenetics DNA technology combination provide powerful tools elucidate genes. A method allowing assignment G1m(a+) G1m(a-) at level polymerase chain reaction analysis recently briefly described.