Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles

摘要: When nanoparticles (NPs) enter into biological systems, proteins would interact with NPs to form the protein corona that can critically impact identity of nanomaterial. Owing their fundamental scientific interest and potential applications, Fe3O4 different sizes have been developed for applications in cell separation as contrast agents magnetic resonance imaging (MRI), etc. Here, we investigated whether nanoparticle size affects formation coronas around NPs. Both identification quantification results demonstrated particle does play an important role plasma on NPs; it not only influenced composition formed but also affected abundances within coronas. Understanding binding profiles human facilitate exploration bio-distributions fates systems.