Healthspan pathway maps in C. elegans and humans highlight transcription, prolifera-tion/biosynthesis and lipids

摘要: The molecular basis of aging and aging-related diseases is being unraveled at an increas-ing pace. More recently, a long healthspan seen as important goal. However, precise definition health not straightforward, the causal "per se" largely unknown. Here, we define based on dysfunc-tions. Based extensive review literature, in particular for humans C. elegans, compile list features genes associated with them. Clusters these interaction annotation data give rise to maps health-span pathways humans, featuring themes transcription initiation, proliferation cho-lesterol/lipid processing, immune response mitochondrion. Overlaying healthspan-related gene expression (describing effects metabolic intervention improvements health) onto aforementioned pathway maps, observe downregulation Notch signalling proliferation/cell-cycle elegans; former reflects proinflammatory role pathway. Investigating overlap identify transcription, proliferation/biosynthesis lipids common theme an-notation level, proliferation-related kinases gene/protein level. Our literature-based corpus, including visualization, available reference future investigations, http://www.h2020awe.eu/index.php/pathways/.