Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation.
作者： N. Ozaki , K.A. Matheis , M. Gamber , T. Feidl , T. Nolte
DOI: 10.1016/J.ETP.2009.07.004
关键词:
摘要: For the application of microarray technology as an additional endpoint in toxicological studies, there is a need to understand associations between pathological processes and gene expression alterations. In current study, we investigated gentamicin nephrotoxic model compound. Gene changes kidney response dose 80 mg/kg were analyzed by using DNA alterations associated with results from conventional histopathological investigations described pathomechanisms gentamicin. Under conditions our experiment, mRNA level 211 genes found be deregulated The gentamicin-induced affection proximal convoluted tubules was strong up-regulation mRNAs encoding for proteins which are used nephrotoxicity markers urine plasma such Kim-1, Osteopontin TIMP1. Candidate marker GATM deregulated. Gentamicin-induced lysosomal phospholipidosis indicated deregulation located products ATP6V1D, subunit H+ transporting ATPase. Effects on glucose transport metabolism down-regulation SGLT-2 glucose-6-phoshatase. Renal cell apoptosis up-regulated TP53 BAX. role oxidative stress toxicity reflected transferrin receptor heme oxygenase. study show potential complex mechanism single study.
elsevier.com
sci-hub.se 参考文章(90)
W. M. Bennett, L. M. Mela-Riker, D. C. Houghton, D. N. Gilbert, W. C. Buss, Microsomal protein synthesis inhibition: an early manifestation of gentamicin nephrotoxicity. American Journal of Physiology-renal Physiology. ,vol. 255, ,(1988) , 10.1152/AJPRENAL.1988.255.2.F265
Curt D. Wolfgang, Tsonwin Hai, Amy E. Allen, Derek K. Marsee, Umasundari Sivaprasad, ATF3 and stress responses. Gene Expression. ,vol. 7, pp. 321- 335 ,(1999)
V. U. Collier, M. Walser, Creatinine Metabolism in Chronic Renal Failure Clinical Science. ,vol. 58, pp. 327- 335 ,(1980) , 10.1042/CS0580327
Christopher D. Gocke, Stephen A. Osmani, Barbara A. Miller, The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in dividing cells and ciliated epithelia Histochemistry and Cell Biology. ,vol. 114, pp. 293- 301 ,(2000) , 10.1007/S004180000197
B. Marescau, I.A. Qureshi, V. Stalon, P.P. De Deyn, Guanidino compounds in biology and medicine John Libbey. ,(1992)
Deanna S. Smith, Martin Niethammer, Ramses Ayala, Ying Zhou, Michael J. Gambello, Anthony Wynshaw-Boris, Li-Huei Tsai, Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1 Nature Cell Biology. ,vol. 2, pp. 767- 775 ,(2000) , 10.1038/35041000
Hardman JG Ed, Goodman & Gilman's The Pharmacological Basis of Therapeutics ,(1985)
P Guthmiller, D M McGuire, J F Van Pilsum, J R Boen, Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine. Journal of Biological Chemistry. ,vol. 269, pp. 17556- 17560 ,(1994) , 10.1016/S0021-9258(17)32477-8
Shu-Chan Hsu, Daniel TerBush, Mathew Abraham, Wei Guo, The Exocyst Complex in Polarized Exocytosis International Review of Cytology-a Survey of Cell Biology. ,vol. 233, pp. 243- 265 ,(2004) , 10.1016/S0074-7696(04)33006-8
W. J. Welch, Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease Physiological Reviews. ,vol. 72, pp. 1063- 1081 ,(1992) , 10.1152/PHYSREV.1992.72.4.1063