Effects of cigarette nicotine content and smoking pace on subsequent craving and smoking.

摘要: Abstract Rationale. The relative contribution of sensory and pharmacological variables in regulating craving smoking remains unclear. Rapid procedures denicotinized cigarettes can be used to further disentangle these factors, explore the relationship between smoking. Objective. present study examined role nicotine cues mediating smoking, Methods. Participants (n=15) engaged one session each rapid (up nine with puffs taken every 6 s) normal paced nicotinized (total four sessions). During next 3 h, withdrawal assessments opportunities were scheduled 15 min. Plasma levels measured at baseline, immediately 15 min after interventions, subsequently time when participant first chose smoke. Results. Craving ratings equally suppressed all conditions. After self-paced conditions, both types produced equivalent effects on latency Latency smoke was significantly longer compared other Finally, changes associated choices Conclusions. regardless pace or content. Only high doses did play an additional acutely suppressing behavior. Small elevations