Enhancement of the cytolytic effect of anti-bacterial cecropin by the microvilli of cancer cells.

摘要: A comparison between IC50s of cecropin B on tumor cells such as KG-1 leukemia and Ags stomach carcinoma and non-tumor cells like fibroblasts and red blood cells was conducted. The IC50s of cecropin B for KG-1 leukemia and Ags carcinoma cells were 20.8+/-2.3 microM (MTT) and 18.9+/-3.3 microM (trypan blue) and 16.0+/-3.5 microM (MTT) & 15.3+/-3.7 microM (trypan blue), respectively. The IC50 of cecropin B for 3T6 fibroblast cells was 92.0+/-9.1 microM by MTT assay and the HE50 of cecropin B for human red blood cells was 180.0+ …