Qualitative Platelet Defects with Reduced Life-Span in Acute Leukaemia*

摘要: Summary: Qualitative platelet abnormalities, as well thrombocytopenia, may contribute to the haemorrhagic diathesis in acute leukaemia. The prevalence of impaired function, reflected by aggregation response ADP, adrenaline and Ristocetin, factor III activity, was assessed 21 patients with During phases active disease or partial remission, and/or defective lll release occurred eleven fifteen three five remission. In complete function normal. associated reduced autologous life-spans, whilst normal coupled survival. Although mechanisms for production thrombocytopenia leukaemia are multifactorial, it is suggested that acquisition platelets survival play a contributory role.