Clinicopathologic factors associated with de novo metastatic breast cancer

摘要: Abstract While breast cancers with distant metastasis at presentation (de novo metastasis) harbor significantly inferior clinical outcomes, there have been limited studies analyzing the clinicopathologic characteristics in this subset of patients. In study, we analyzed 6126 diagnosed between 1998 and 2013 to identify factors associated de metastatic cancer. When compared patients without presentation, race, histologic grade, estrogen/progesterone receptor (ER/PR) HER2 statuses were entire cohort, whereas age, PR status significant parameters locally advanced cancer (Stage IIB/III). The had a older mean age lower proportion HER2-positive tumors when those recurrence. Further, HER2-rich subtype demonstrated drastically higher incidence luminal triple-negative cohort [odds ratio (OR) = 5.68 2.27, respectively] disease (OR = 4.02 2.12, respectively), no difference was seen Moreover, subtypes showed bone-seeking (OR = 1.92) liver-homing (OR = 2.99) characteristics, respectively, for sites metastasis, while latter not observed Our data suggest that an algorithm incorporating factors, especially grade profile, remains benefit during decision making newly pursuit precision medicine.