Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer's: A 1-year randomized controlled trial.

摘要: Background Our goal was to investigate the role of physical exercise protect brain health as we age, including potential mitigate Alzheimer’s-related pathology. We assessed effect 52 weeks a supervised aerobic program on amyloid accumulation, cognitive performance, and volume in cognitively normal older adults with elevated sub-threshold levels cerebral measured by PET imaging. Methods findings This 52-week randomized controlled trial compared effects 150 minutes per week vs. education control intervention. A total 117 underactive (mean age 72.9 [7.7]) without evidence impairment, (n = 79) or subthreshold 38) were randomized, 110 participants completed study. Exercise conducted supervision monitoring trained specialists. 18F-AV45 imaging anatomical MRI for whole hippocampal at baseline Week follow-up index health. Neuropsychological tests baseline, 26, assess executive function, verbal memory, visuospatial domains. Cardiorespiratory fitness testing performed response exercise. The group significantly improved cardiorespiratory (11% 1% group) but there no differences change measures amyloid, volume, performance control. Conclusions Aerobic not associated reduced accumulation amyloid. In spite strong systemic intervention, observed lack structure benefits suggests reported other studies are likely be related non-amyloid effects. Trial registration NCT02000583; ClinicalTrials.gov.