Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine.
作者： Clifford L. Cua , Lynette K. Rogers , Louis G. Chicoine , Molly Augustine , Yi Jin
DOI: 10.1007/S00431-010-1361-X
关键词:
摘要: Down syndrome (DS) patients have an increased risk of developing pulmonary hypertension (PH). Increased plasma levels asymmetric dimethylarginine (ADMA) may contribute to vascular dysfunction in adults with idiopathic hypertension. Our goal was test the hypothesis that DS PH higher ADMA than without PH. definitive (n = 6) and no evidence 12) were studied. Plasma arginine, ADMA, nitrite/nitrate (NOx; stable metabolites nitric oxide (NO)) measured. arginine concentration lower (p < 0.05) (23 ± 11 μM) versus non-PH (46 24 μM). 0.005) (18.0 4.2 (8.6 5.9 NOx (4.5 1.7 (8.5 7.3 These results are consistent contributing NO production suggest be a potential biomarker for patients.
springer.com
sci-hub.se 参考文章(31)
Shigeo Yamaki, Hisataka Yasui, Hideaki Kado, Kunihiro Yonenaga, Yuichiro Nakamura, Toshio Kikuchi, Hiroshi Ajiki, Minoru Tsunemoto, Hitoshi Mohri, Pulmonary vascular disease and operative indications in complete atrioventricular canal defect in early infancy The Journal of Thoracic and Cardiovascular Surgery. ,vol. 106, pp. 398- 405 ,(1993) , 10.1016/S0022-5223(19)34071-1
C Girard, V Dutheil, B Maitrasse, D Godin-Ribuot, P Girardet, C C Arvieux, J M Fargnoli, Inhaled nitric oxide: effects on hemodynamics, myocardial contractility, and regional blood flow in dogs with mechanically induced pulmonary artery hypertension. Journal of Heart and Lung Transplantation. ,vol. 15, pp. 700- 708 ,(1996)
Zia Q. Farooki, William L. Jackson, Peter P. Karpawich, Mehdi Hakimi, Eduardo Arciniegas, Edward W. Green, William W. Pinsky, Sandra Clapp, Burton L. Perry, Down's syndrome, complete atrioventricular canal, and pulmonary vascular obstructive disease. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 100, pp. 115- 121 ,(1990) , 10.1016/S0022-5223(19)35606-5
Beyer, Kolditz, Ewert, Rubens, Opitz, Schellong, Hoeffken, Halank, L-arginine plasma levels and severity of idiopathic pulmonary arterial hypertension. Vasa-european Journal of Vascular Medicine. ,vol. 37, pp. 61- 67 ,(2008) , 10.1024/0301-1526.37.1.61
Torbj??rn Holm, P??l Aukrust, Erik Aagaard, Thor Ueland, Tor S. Haugstad, John Kjekshus, Svein Simonsen, Stig S. Fr??land, Lars Gullestad, Arne K. Andreassen, Hypertension in relation to nitric oxide, asymmetric dimethylarginine, and inflammation: different patterns in heart transplant recipients and individuals with essential hypertension. Transplantation. ,vol. 74, pp. 1395- 1400 ,(2002) , 10.1097/00007890-200211270-00009
W.H. Wilson Tang, Zeneng Wang, Leslie Cho, Danielle M. Brennan, Stanley L. Hazen, Diminished Global Arginine Bioavailability and Increased Arginine Catabolism as Metabolic Profile of Increased Cardiovascular Risk Journal of the American College of Cardiology. ,vol. 53, pp. 2061- 2067 ,(2009) , 10.1016/J.JACC.2009.02.036
Hiroyuki Fukushima, Kenjiro Kosaki, Reiko Sato, Tatsuhiko Yagihashi, Ryohei Gatayama, Kazuki Kodo, Takuya Hayashi, Maki Nakazawa, Takatoshi Tsuchihashi, Jun Maeda, Yoshifumi Kojima, Hiroyuki Yamagishi, Takao Takahashi, Mechanisms underlying early development of pulmonary vascular obstructive disease in Down syndrome: An imbalance in biosynthesis of thromboxane A2 and prostacyclin. American Journal of Medical Genetics Part A. ,vol. 152, pp. 1919- 1924 ,(2010) , 10.1002/AJMG.A.33555
Francesca Mallamaci, Giovanni Tripepi, Sebastiano Cutrupi, Lorenzo S. Malatino, Carmine Zoccali, Prognostic value of combined use of biomarkers of inflammation, endothelial dysfunction, and myocardiopathy in patients with ESRD Kidney International. ,vol. 67, pp. 2330- 2337 ,(2005) , 10.1111/J.1523-1755.2005.00338.X
NORITOSHI NAGAYA, MASAAKI UEMATSU, HIDEO OYA, NAGATO SATO, FUMIO SAKAMAKI, SHINGO KYOTANI, KAZUYUKI UENO, NORIFUMI NAKANISHI, MASAKAZU YAMAGISHI, KUNIO MIYATAKE, Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. ,vol. 163, pp. 887- 891 ,(2001) , 10.1164/AJRCCM.163.4.2007116
D. McCormack, Endothelium-derived relaxing factors and the human pulmonary circulation. Lung. ,vol. 168, pp. 35- 42 ,(1990) , 10.1007/BF02718111