Taurine mitigates cognitive impairment induced by chronic co-exposure of male Wistar rats to chlorpyrifos and lead acetate
作者： M.G. Akande , Y.O. Aliu , S.F. Ambali , J.O. Ayo
DOI: 10.1016/J.ETAP.2013.11.023
关键词:
摘要: Abstract Organophosphate pesticides and heavy metals are ubiquitous environmental pollutants neurotoxicants. We investigated the effects of taurine (an antioxidant; TA) on oxidative stress cognition in male Wistar rats co-treated with chlorpyrifos organophosphate pesticide; CPF) lead acetate (heavy metal; LA). The were divided into 5 groups 10 each. first two administered distilled water soya oil respectively. remaining three (TA), 50 mg/kg body weight, CPF + LA group [CPF (4.25 mg/kg, 1/20 LD50] LA (233.25 mg/kg, LD50) TA + CPF + LA [TA (50 mg/kg), CPF (4.25 mg/kg) (233.25 mg/kg)]. xenobiotics once daily by oral gavage for 16 weeks. results showed reductions activities brain antioxidant enzymes acetylcholinesterase, increased lipoperoxidation histopathological alterations cerebral cortex group. However, TA mitigated perturbations counteracted attenuated neuronal degeneration induced joint LA-induced neurotoxicity. suggested that is neuroprotective following chronic co-exposure to LA.
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sci-hub.se 参考文章(84)
Fu Yu, Ziren Wang, Bao Ju, Yongqiang Wang, Jing Wang, Decheng Bai, Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamins C and E. Experimental and Toxicologic Pathology. ,vol. 59, pp. 415- 423 ,(2008) , 10.1016/J.ETP.2007.11.007
C.H. Walker, Biochemical biomarkers in ecotoxicology--some recent developments. Science of The Total Environment. ,vol. 171, pp. 189- 195 ,(1995) , 10.1016/0048-9697(95)04720-6
Gennaro Giordano, Zhara Afsharinejad, Marina Guizzetti, Annabella Vitalone, Terrance J. Kavanagh, Lucio G. Costa, Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology. ,vol. 219, pp. 181- 189 ,(2007) , 10.1016/J.TAAP.2006.09.016
Yusuf Kalender, Sinan Kaya, Dilek Durak, Fatma Gokce Uzun, Filiz Demir, Protective effects of catechin and quercetin on antioxidant status, lipid peroxidation and testis-histoarchitecture induced by chlorpyrifos in male rats. Environmental Toxicology and Pharmacology. ,vol. 33, pp. 141- 148 ,(2012) , 10.1016/J.ETAP.2011.12.008
M.-M Mesulam, A Guillozet, P Shaw, A Levey, E.G Duysen, O Lockridge, Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine Neuroscience. ,vol. 110, pp. 627- 639 ,(2002) , 10.1016/S0306-4522(01)00613-3
Anugya Mehta Anugya Mehta, RS Verma, Nalini Srivastava Nalini Srivastava, Chlorpyrifos induced alterations in the levels of hydrogen peroxide, nitrate and nitrite in rat brain and liver Pesticide Biochemistry and Physiology. ,vol. 94, pp. 55- 59 ,(2009) , 10.1016/J.PESTBP.2009.04.001
Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Mahua Sinha, Parames C. Sil, Arsenic-induced oxidative cerebral disorders: Protection by taurine Drug and Chemical Toxicology. ,vol. 32, pp. 93- 102 ,(2009) , 10.1080/01480540802564171
Lara Boatti, Elisa Robotti, Emilio Marengo, Aldo Viarengo, Francesco Marsano, Effects of Nickel, Chlorpyrifos and Their Mixture on the Dictyostelium discoideum Proteome International Journal of Molecular Sciences. ,vol. 13, pp. 15679- 15705 ,(2012) , 10.3390/IJMS131215679
Hande Gurer, Nuran Ercal, Can Antioxidants Be Beneficial in the Treatment of Lead Poisoning Free Radical Biology and Medicine. ,vol. 29, pp. 927- 945 ,(2000) , 10.1016/S0891-5849(00)00413-5
P MEYER, M BROWN, H FALK, Global approach to reducing lead exposure and poisoning Mutation Research-reviews in Mutation Research. ,vol. 659, pp. 166- 175 ,(2008) , 10.1016/J.MRREV.2008.03.003