Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.

作者: F Bloom , D Segal , N Ling , R Guillemin

DOI: 10.1126/SCIENCE.185694

关键词:

摘要: The endogenous morphinomimetic brain peptides Met 5 -enkephalin and α-, β-, and γ-endorphins have been evaluated in rats after intracerebrospinal fluid injection. β-Endorphin …

参考文章(15)
Wei E, Loh Hh, Way El, BRAIN SITES OF PRECIPITATED ABSTINENCE IN MORPHINE-DEPENDENT RATS Journal of Pharmacology and Experimental Therapeutics. ,vol. 185, pp. 108- 115 ,(1973)
Nicholas C. Ling, Jean E. Rivier, Michael W. Monahan, Wylie W. Vale, Analogues of luteinizing hormone releasing factor modified at positions 2, 6, and 10. Journal of Medicinal Chemistry. ,vol. 19, pp. 937- 941 ,(1976) , 10.1021/JM00229A016
P. B. BRADLEY, I. BRIGGS, R. J. GAYTON, LYNN A. LAMBERT, Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem Nature. ,vol. 261, pp. 425- 426 ,(1976) , 10.1038/261425A0
L. H. Lazarus, N. Ling, R. Guillemin, beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 73, pp. 2156- 2159 ,(1976) , 10.1073/PNAS.73.6.2156
HEINZ H. BÜSCHER, RONALD C. HILL, DIETMAR RÖMER, FRANCIS CARDINAUX, ANNEMARIE CLOSSE, DANIEL HAUSER, JANOS PLESS, Evidence for analgesic activity of enkephalin in the mouse Nature. ,vol. 261, pp. 423- 425 ,(1976) , 10.1038/261423A0
J. Hughes, T. W. Smith, H. W. Kosterlitz, Linda A. Fothergill, B. A. Morgan, H. R. Morris, Identification of two related pentapeptides from the brain with potent opiate agonist activity Nature. ,vol. 258, pp. 577- 579 ,(1975) , 10.1038/258577A0
JAMES D. BELLUZZI, NORMAN GRANT, VICTOR GARSKY, DIMITRIOS SARANTAKIS, C. DAVID WISE, LARRY STEIN, Analgesia induced in vivo by central administration of enkephalin in rat Nature. ,vol. 260, pp. 625- 626 ,(1976) , 10.1038/260625A0
B. M. Cox, A. Goldstein, C. H. Hi, Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin Proceedings of the National Academy of Sciences of the United States of America. ,vol. 73, pp. 1821- 1823 ,(1976) , 10.1073/PNAS.73.6.1821