Redox regulation in human melanocytes and melanoma.

摘要: The human melanocyte is continuously exposed to intrinsic and extrinsic sources of reactive biochemical species, but finely tuned via the anti-oxidant radical properties melanin suppress build-up an altered redox phenotype. We propose that this control lost during melanomagenesis inappropriate redox-sensitive transcriptional factor activations occur which result in enhancement anti-apoptotic phenotype transformed cell. This conceptual framework offers testable steps determine role alterations carcinogenic evolution, prevention treatment melanoma other diseases melanocyte.