H-2 mutations: their genetics and effect on immune functions.
作者： Jan Klein
DOI: 10.1016/S0065-2776(08)60229-1
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摘要: Publisher Summary This chapter discusses the use of H-2 mutations to study functions murine major histocompatibility complex. A single locus can control a variety immunologic phenomena, and strong MLC reactions occur H-2K D antigens as well I region antigens. Histogenetically serologically detectable are comparable complexity small changes in molecule—a amino acid substitution—can have drastic effects on phenotype. The describes methods detection analysis general particular. knowledge is related perennial problem polymorphism. individual immune discussed, data presented way change these functions. In allograft reaction—the reaction which based—antigens carried by transplant recognized specific receptors T lymphocytes. vitro studies indicate that cells complex sense different presumably recognize portions molecule.
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