Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies

摘要: Objective To systematically review interventional studies of the effects alcohol consumption on 21 biological markers associated with risk coronary heart disease in adults without known cardiovascular disease. Design Systematic and meta-analysis. Data sources Medline (1950 to October 2009) Embase (1980 limits. Study selection Two reviewers independently selected that examined compared fasting levels specific after use those a period no (controls). 4690 articles were screened for eligibility, full texts 124 reviewed, 63 relevant selected. Results Of eligible studies, 44 13 biomarkers meta-analysed fixed or random models. Quality was assessed by sensitivity analysis grouped design. Analyses stratified type beverage (wine, beer, spirits). Alcohol significantly increased high density lipoprotein cholesterol (pooled mean difference 0.094 mmol/L, 95% confidence interval 0.064 0.123), apolipoprotein A1 (0.101 g/L, 0.073 0.129), adiponectin (0.56 mg/L, 0.39 0.72). showed dose-response relation (test trend P=0.013). decreased fibrinogen (−0.20 −0.29 −0.11) but did not affect triglyceride levels. Results similar crossover before across types. Conclusions Favourable changes several (higher lower fibrinogen) provide indirect pathophysiological support protective effect moderate disease.