Perinatal Exposure to Bisphenol A at Reference Dose Predisposes Offspring to Metabolic Syndrome in Adult Rats on a High-Fat Diet

摘要: Bisphenol A (BPA), a widely used environmental endocrine disruptor, has been reported to disrupt glucose homeostasis. BPA exposure may be risk factor for type 2 diabetes. In this study, we investigated the effects of early-life on metabolic syndrome in rat offspring fed normal diet and high-fat diet. Pregnant Wistar rats were exposed (50, 250, or 1250 μg/kg · d) corn oil throughout gestation lactation by oral gavage. Offspring after weaning. Body weight, parameters lipid metabolism, morphology, function β-cells measured offspring. On diet, perinatal 50 d resulted increased body elevated serum insulin, impaired tolerance adult such detrimental accelerated exacerbated. Furthermore, severe syndrome, including obesity, dyslipidemia, hyperleptindemia, hyperglycemia, hyperinsulinemia, intolerance, was observed high-fat-fed perinatally BPA. No adverse effect at 250 no matter These results suggest that reference dose, but not high impairs predisposes High-fat intake is trigger initiates