Apoptotic Regulators and Its Clinical Implications in Mammary Carcinoma

作者: Subhadeep Das , Malay Chatterjee

DOI: 10.1007/978-94-007-4917-7_9

关键词:

摘要: Today, this is an established fact that like other organs, normal breast development also used to be monitored by a balance between cell proliferation and apoptosis. As consequence, tumor growth not outcome of abnormal only, but reduced apoptosis, too. Apoptosis or programmed death maintains the integrity healthy individual, while dysregulation mechanism becomes crucial for pathophysiology tumorigenesis. Bcl-2 family proteins, caspaes, IAP TNF superfamily members are important regulators apoptotic signaling pathways. Therefore, several therapeutic agents have been exploited targeting these The review has concentrated on physiology different their intervention towards cancer.

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