Compared Efficacy of Preservation Solutions in Liver Transplantation: A Long‐Term Graft Outcome Study From the European Liver Transplant Registry

摘要: Between 2003 and 2012, 42 869 first liver transplantations performed in Europe with the use of either University Wisconsin solution (UW; N = 24 562), histidine-tryptophan-ketoglutarate(HTK; N = 8696), Celsior (CE; N = 7756) or Institute Georges Lopez preservation (IGL-1; N = 1855) preserved grafts. Alternative solutions to UW were increasingly used during last decade. Overall, 3-year graft survival was higher UW, IGL-1 CE (75%, 75% 73%, respectively), compared HTK (69%) (p  12 h grafts for patients cancer (p < 0.0001). For partial grafts, 89% IGL-1, 67% 68% 64% (p = 0.009). Multivariate analysis identified as an independent factor loss, recipient HIV (+), donor age ≥65 years, HCV main disease acute hepatic failure, a graft, ≥60 no identical ABO compatibility, hepatitis B surface antigen (−), TIT ≥ 12 h, male other than cirrhosis. appears be risk loss. Both lesser extent, provides similar results full size deceased tends offer best outcome.