Cross-linking of monocyte plasma membrane Fc alpha, Fc gamma or mannose receptors induces TNF production.

摘要: We have studied and compared the effects of IgA IgG immune complexes concanavalin A (Con A) on human monocyte tumour necrosis factor (TNF) production. The presence IgA-containing in monolayers resulted a dose-dependent increase TNF Similar results were obtained with IgG-containing Con A. monomeric or did not secretion. Both also increased interleukin-1 beta (IL-1 beta) Galactose inhibited effect but complexes, while mannose Prednisolone abrogated production, indomethacin enhanced production all instances where cross-linking plasma membrane receptors was achieved. These indicate that activation Fc alpha (Fc R), gamma R by IL-1 findings may be particular relevance pathogenesis complex-mediated disease.