CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation.
作者： L Quteineh , PY Bochud , D Golshayan , S Crettol , JP Venetz
DOI: 10.1038/TPJ.2015.82
关键词:
摘要: Metabolic syndrome after transplantation is a major concern following solid organ (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. effect of CRTC2 polymorphisms on new-onset diabetes (NODAT) was investigated in discovery sample SOT recipients (n1=197). Positive results were tested for replication two samples from the Swiss Transplant Cohort Study (STCS, n2=1294 and n3=759). Obesity other metabolic traits also tested. Associations with population-based (n4=46'186, n5=123'865, n6>100,000) finally analyzed. In sample, rs8450-AA genotype associated NODAT, fasting blood body mass index (Pcorrected A significantly several abnormalities. rs8450G>A appears to have an important role high prevalence observed patients SOT. weak association samples.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.82.
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