Differential effects of low glucose concentrations on seizures and epileptiform activity in vivo and in vitro.

摘要: In vivo, severe hypoglycemia is frequently associated with seizures. The hippocampus a structure prone to develop seizures and seizure-induced damage. Patients repeated hypoglycemic episodes have frequent memory problems, suggesting impaired hippocampal function. Here we studied the effects of moderate on primarily generalized flurothyl-induced in vivo and, using EEG recordings, determined involvement Moderate systemic had proconvulsant clonic (forebrain) During seizures, seizure discharges were recorded hippocampus. Thus, continued studies combined entorhinal cortex-hippocampus slices vitro. However, vitro, decreases extracellular glucose from baseline 10 mM 2 or 1 did not induce any epileptiform discharges. fact, low (2 mM) attenuated preexisting low-Mg2+-induced activity cortex CA1 region. Osmolarity compensation low-glucose solution mannitol slice recovery. Additionally, paired-pulse stimuli that there was no impairment GABAA inhibition dentate gyrus during glucopenia. data strongly indicate that, although forebrain susceptibility increased involved depletion vitro contributes an arrest system network net