Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation.
作者： Diana E. Aziz , Aly A. Abdelbary , Abdelhalim I. Elassasy
DOI: 10.1080/10717544.2018.1451572
关键词:
摘要: AbstractDiacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN administration associated diarrhea which represent...
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