Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.

摘要: Innovation in electrode design has produced a myriad of new and creative strategies for interfacing the nervous system with softer, less invasive, more broadly distributed sites high spatial resolution. However, despite rapid growth use implanted arrays research clinical applications, there are no accepted guiding principles biocompatible chronic recording interfaces central (CNS). Studies suggest that architecture flexibility devices play important roles determining effective tissue integration: device feature dimensions (varying from 'sub'- to 'supra'-cellular scales, 100 µm), Young's modulus, bending modulus have all been identified as key features design. critical knowledge gaps remain field respect underlying motivation these designs: (1) systematic study relationship between (materials, architecture, flexibility), biointegration, signal quality needs be performed, including controls interaction effects features, (2) benchmarks success need determined (biological integration, performance, longevity, stability), (3) user results, particularly those champion specific or modification, replicated across laboratories. Finally, ancillary factors such tethering, site impedance insertion method considered. Here, we briefly review observations to-date on integration then highlight comprehensive testing moving forward.