FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome.

Matteo Menotti, Chiara Ambrogio, Taek-Chin Cheong, Chiara Pighi, Ines Mota, Seth H. Cassel, Mara Compagno, Qi Wang, Riccardo Dall’Olio, Valerio G. Minero, Teresa Poggio, Geeta Geeta Sharma, Enrico Patrucco, Cristina Mastini, Ramesh Choudhari, Achille Pich, Alberto Zamo, Roberto Piva, Silvia Giliani, Luca Mologni, Clayton K. Collings, Cigall Kadoch, Carlo Gambacorti-Passerini, Luigi D. Notarangelo, Ines M. Anton, Claudia Voena, Roberto Chiarle, Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma Nature Medicine. ,vol. 25, pp. 130- 140 ,(2019) , 10.1038/S41591-018-0262-9

Tangjingjun Liu, Lei Xia, Yao Yao, Chen Yan, Yanhua Fan, Babu Gajendran, Jue Yang, You-Jun Li, Juan Chen, Jorge Filmus, David E Spaner, Eldad Zacksenhaus, Xiaojiang Hao, Yaacov Ben-David, Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis Cell Death and Disease. ,vol. 10, pp. 117- 117 ,(2019) , 10.1038/S41419-019-1363-1

Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew A. Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William C. Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd R. Golub, Levi A. Garraway, William R. Sellers, Mahmoud Ghandi, Franklin W. Huang, Judit Jané-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald, Jordi Barretina, Ellen T. Gelfand, Craig M. Bielski, Haoxin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, François Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael S. Lawrence, Rehan Akbani, Yiling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Next-generation characterization of the Cancer Cell Line Encyclopedia Nature. ,vol. 569, pp. 503- 508 ,(2019) , 10.1038/S41586-019-1186-3

Shaoyan Hu, Shuiyan Wu, Sudan He, Yunjing Zheng, Meng Wu, Qin Lu, Xiaoliang Yu, The WASP P460S Mutation Causes a New Phenotype of WASP Mutations Related Disorder: X-Linked Pancytopenia Blood. ,vol. 130, pp. 1044- 1044 ,(2017) , 10.1182/BLOOD.V130.SUPPL_1.1044.1044

DK Watson, DG Blair, GJ Mavrothalassitis, XK Zhang, M Athanasiou, PA Clausen, Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth & Differentiation. ,vol. 7, pp. 1525- 1534 ,(1996)

Ben-David Y, Cheong Gy, Lavigueur A, Bernstein A, Insertional inactivation of the p53 gene during friend leukemia: a new strategy for identifying tumor suppressor genes. The New biologist. ,vol. 2, pp. 1015- ,(1990)

Violaine Moreau, Friedrich Frischknecht, Inge Reckmann, Renaud Vincentelli, Gwénaël Rabut, Donn Stewart, Michael Way, A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nature Cell Biology. ,vol. 2, pp. 441- 448 ,(2000) , 10.1038/35017080

Jeffrey R Peterson, Lincoln C Bickford, David Morgan, Annette S Kim, Ouathek Ouerfelli, Marc W Kirschner, Michael K Rosen, Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation Nature Structural & Molecular Biology. ,vol. 11, pp. 747- 755 ,(2004) , 10.1038/NSMB796

Gabriel Rabeharivelo, Nathalie Morin, Guillaume Bompard, Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway BMC Cell Biology. ,vol. 9, pp. 42- 42 ,(2008) , 10.1186/1471-2121-9-42

Kohsuke Imai, Tomohiro Morio, Yi Zhu, Yinzhu Jin, Sukeyuki Itoh, Michiko Kajiwara, Jun-ichi Yata, Shuki Mizutani, Hans D. Ochs, Shigeaki Nonoyama, Clinical course of patients with WASP gene mutations Blood. ,vol. 103, pp. 456- 464 ,(2004) , 10.1182/BLOOD-2003-05-1480