How best to ventilate? Trial design and patient safety in studies of the acute respiratory distress syndrome.

摘要: Each year, about 150,000 people in the United States have acute lung injury or its most severe form, respiratory distress syndrome — devastating diseases associated with a mortality rate of between 30 and 50 percent. Despite injury, pulmonary function survivors returns nearly to normal within 6 12 months. Unfortunately, search for effective treatments keep patients alive while their lungs heal has lagged behind substantial progress basic research. Almost all that been tested clinical trials not worked.1,2 After years bad news, . . .