Curcumin-loaded dual pH- and thermo-responsive magnetic microcarriers based on pectin maleate for drug delivery.
作者： Elizângela A.M.S. Almeida , Ismael C. Bellettini , Francielle P. Garcia , Maroanne T. Farinácio , Celso V. Nakamura
DOI: 10.1016/J.CARBPOL.2017.05.034
关键词:
摘要: Magnetic microgels with pH- and thermo-responsive properties were developed from the pectin maleate, N-isopropyl acrylamide, Fe3O4 nanoparticles. The hybrid materials characterized by infrared spectroscopy, scanning electron microscope coupled X-ray energy dispersive wide angle scattering, Zeta potential, magnetization hysteresis measurements. Curcumin (CUR) was loaded into microgels, release assays carried out in simulated environments (SGF SIF) at different conditions of temperature (25 or 37°C). A slow sustainability CUR achieved under external magnetic field influence. Loaded displayed stability, bioavailability greater solubility regarding free CUR. Besides, cytotoxicity showed that without could suppress Caco-2 cells growth. So, be tailored to elicit hybrid-based satisfactory application medical arena.
sci-hub.se 参考文章(43)
Erik Brewer, Jason Coleman, Anthony Lowman, Emerging technologies of polymeric nanoparticles in cancer drug delivery Journal of Nanomaterials. ,vol. 2011, pp. 1- 10 ,(2011) , 10.1155/2011/408675
Wei Shi, Sukanta Dolai, Samar Rizk, Afshan Hussain, Hussnain Tariq, Saadyah Averick, William L'Amoreaux, Abdeslem El Idrissi, Probal Banerjee, Krishnaswami Raja, Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications. Organic Letters. ,vol. 9, pp. 5461- 5464 ,(2007) , 10.1021/OL702370M
Radha K. Maheshwari, Anoop K. Singh, Jaya Gaddipati, Rikhab C. Srimal, Multiple biological activities of curcumin: a short review. Life Sciences. ,vol. 78, pp. 2081- 2087 ,(2006) , 10.1016/J.LFS.2005.12.007
Anand D. Tiwari, Ajay K. Mishra, Shivani B. Mishra, Omotayo A. Arotiba, Bhekie B. Mamba, Green synthesis and stabilization of gold nanoparticles in chemically modified chitosan matrices International Journal of Biological Macromolecules. ,vol. 48, pp. 682- 687 ,(2011) , 10.1016/J.IJBIOMAC.2011.02.008
Marcos R Guilherme, Adriano V Reis, Alexandre T Paulino, Thais A Moia, Luiz HC Mattoso, Elias B Tambourgi, None, Pectin‐based polymer hydrogel as a carrier for release of agricultural nutrients and removal of heavy metals from wastewater Journal of Applied Polymer Science. ,vol. 117, pp. 3146- 3154 ,(2010) , 10.1002/APP.32123
Elisangela P. da Silva, Danielly L.A. Sitta, Vanessa H. Fragal, Thelma S.P. Cellet, Marcos R. Mauricio, Francielle P. Garcia, Celso V. Nakamura, Marcos R. Guilherme, Adley F. Rubira, Marcos H. Kunita, Covalent TiO2/pectin microspheres with Fe3O4 nanoparticles for magnetic field-modulated drug delivery International Journal of Biological Macromolecules. ,vol. 67, pp. 43- 52 ,(2014) , 10.1016/J.IJBIOMAC.2014.02.035
Dong-Hyun Kim, Kyoung-Nam Kim, Kwang-Mahn Kim, Yong-Keun Lee, Targeting to carcinoma cells with chitosan- and starch-coated magnetic nanoparticles for magnetic hyperthermia Journal of Biomedical Materials Research Part A. ,vol. 88A, pp. 1- 11 ,(2009) , 10.1002/JBM.A.31775
Challa SSR Kumar, Faruq Mohammad, None, Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery Advanced Drug Delivery Reviews. ,vol. 63, pp. 789- 808 ,(2011) , 10.1016/J.ADDR.2011.03.008
Pedro VA Bueno, Paulo R Souza, Heveline DM Follmann, Antonio GB Pereira, Alessandro F Martins, Adley F Rubira, Edvani C Muniz, None, N,N-Dimethyl chitosan/heparin polyelectrolyte complex vehicle for efficient heparin delivery. International Journal of Biological Macromolecules. ,vol. 75, pp. 186- 191 ,(2015) , 10.1016/J.IJBIOMAC.2015.01.030
Jen-Hung Fang, Yen-Ho Lai, Tsung-Lang Chiu, You-Yin Chen, Shang-Hsiu Hu, San-Yuan Chen, Magnetic Core-Shell Nanocapsules with Dual-Targeting Capabilities and Co-Delivery of Multiple Drugs to Treat Brain Gliomas Advanced Healthcare Materials. ,vol. 3, pp. 1250- 1260 ,(2014) , 10.1002/ADHM.201300598