Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-1 Reduces Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice

作者: M. Rouis , C. Adamy , N. Duverger , P. Lesnik , P. Horellou

DOI: 10.1161/01.CIR.100.5.533

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摘要: … Science..1996; 273:966–968.To evaluate the impact of tissue inhibitor of metalloproteinase (TIMP-1) on atherogenesis, we infused apolipoprotein E–deficient mice fed a lipid-rich diet …

参考文章(47)
Reza Forough, Holly Lea, Barry Starcher, Eric Allaire, Monika Clowes, David Hasenstab, Alexander W. Clowes, Metalloproteinase Blockade by Local Overexpression of TIMP-1 Increases Elastin Accumulation in Rat Carotid Artery Intima Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 18, pp. 803- 807 ,(1998) , 10.1161/01.ATV.18.5.803
L D Stratford-Perricaudet, I Makeh, M Perricaudet, P Briand, Widespread long-term gene transfer to mouse skeletal muscles and heart. Journal of Clinical Investigation. ,vol. 90, pp. 626- 630 ,(1992) , 10.1172/JCI115902
P R Moreno, E Falk, I F Palacios, J B Newell, V Fuster, J T Fallon, Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture. Circulation. ,vol. 90, pp. 775- 778 ,(1994) , 10.1161/01.CIR.90.2.775
H. E. Van Wart, H. Birkedal-Hansen, The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 5578- 5582 ,(1990) , 10.1073/PNAS.87.14.5578
D.F. Busiek, F.P. Ross, S McDonnell, G Murphy, L.M. Matrisian, H.G. Welgus, The matrix metalloprotease matrilysin (PUMP) is expressed in developing human mononuclear phagocytes. Journal of Biological Chemistry. ,vol. 267, pp. 9087- 9092 ,(1992) , 10.1016/S0021-9258(19)50392-1
Y Nakashima, A S Plump, E W Raines, J L Breslow, R Ross, ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 14, pp. 133- 140 ,(1994) , 10.1161/01.ATV.14.1.133
V S Kashyap, S Santamarina-Fojo, D R Brown, C L Parrott, D Applebaum-Bowden, S Meyn, G Talley, B Paigen, N Maeda, H B Brewer, Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors. Journal of Clinical Investigation. ,vol. 96, pp. 1612- 1620 ,(1995) , 10.1172/JCI118200
I. Halpert, U. I. Sires, J. D. Roby, S. Potter-Perigo, T. N. Wight, S. D. Shapiro, H. G. Welgus, S. A. Wickline, W. C. Parks, Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9748- 9753 ,(1996) , 10.1073/PNAS.93.18.9748