Protease-degradable PEG-maleimide coating with on-demand release of IL-1Ra to improve tissue response to neural electrodes.

摘要: Neural electrodes are an important part of brain-machine interface devices that can restore functionality to patients with sensory and movement disorders. Chronically implanted neural induce unfavorable tissue response which includes inflammation, scar formation, neuronal cell death, eventually causing loss electrode function. We developed a poly(ethylene glycol) hydrogel coating for non-fouling characteristics, incorporated anti-inflammatory agent, engineered stimulus-responsive degradable portion on-demand release the agent in inflammatory stimuli. This reduces in vitro glial adhesion, spreading, cytokine compared uncoated controls. also analyzed in vivo using immunohistochemistry microarray qRT-PCR. Although no differences were observed among coated markers, lower IgG penetration into around PEG+IL-1Ra indicates improvement blood-brain barrier integrity. Gene expression analysis showed higher IL-6 MMP-2 samples, as well increase CNTF expression, marker survival. Importantly, increased survival controls was observed. Collectively, these results indicate promising findings improve electrodes.