RNA diversity has profound effects on the translation of neuronal nitric oxide synthase
作者： Y. Wang , D. C. Newton , G. B. Robb , C.-L. Kau , T. L. Miller
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摘要: A comprehensive analysis of the structure neuronal nitric oxide synthase (nNOS; EC 1.14.13.39) mRNA species revealed NOS1 to be most structurally diverse human gene described date in terms promoter usage. Nine unique exon 1 variants are variously used for transcript initiation tissues, and each is expressed from a 5′-flanking region. The dependence on genomic regions control transcription cell-specific fashion burdens transcripts with complex 5′-mRNA leader sequences. Elaborate splicing patterns that involve alternatively spliced exons skipping have been superimposed this diversity. Highly structured nNOS 5′-untranslated regions, which profound effects translation both vitro cells, contain cis RNA elements modulate translational efficiency response changes cellular phenotype.
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