Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation

摘要: Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which commonly found in PXA, has recently been detected approximately 50 % all epithelioid glioblastoma (GBM) cases. We herein report case GBM developing site left temporal PXA 13 years after treatment primary tumor. The V600E mutation was both tumors. These findings suggest that may arise from mutation.