Reversion to an embryonic alternative splicing program enhances leukemia stem cell self-renewal

作者: Frida Holm , Eva Hellqvist , Cayla N. Mason , Shawn A. Ali , Nathaniel Delos-Santos

DOI: 10.1073/PNAS.1506943112

关键词:

摘要: … stem cell (LSC) maintenance in mouse models (12–14), CD44 … with human IL-3, CM-CSF, and stem cell factor (SCF). … CD44 splice variant results using isoform-specific primers. …

参考文章(43)
S. Legras, U. Günthert, R. Stauder, F. Curt, S. Oliferenko, H.C. Kluin-Nelemans, J.P. Marie, S. Proctor, C. Jasmin, F. Smadja-Joffe, A strong expression of CD44-6v correlates with shorter survival of patients with acute myeloid leukemia Blood. ,vol. 91, pp. 3401- 3413 ,(1998) , 10.1182/BLOOD.V91.9.3401
Henk Rozemuller, Shosh Knaän-Shanzer, Anton Hagenbeek, Louis van Bloois, Gert Storm, Anton C.M. Martens, Enhanced engraftment of human cells in RAG2/γc double-knockout mice after treatment with CL2MDP liposomes Experimental Hematology. ,vol. 32, pp. 1118- 1125 ,(2004) , 10.1016/J.EXPHEM.2004.08.002
Kolja Eppert, Katsuto Takenaka, Eric R Lechman, Levi Waldron, Björn Nilsson, Peter van Galen, Klaus H Metzeler, Armando Poeppl, Vicki Ling, Joseph Beyene, Angelo J Canty, Jayne S Danska, Stefan K Bohlander, Christian Buske, Mark D Minden, Todd R Golub, Igor Jurisica, Benjamin L Ebert, John E Dick, Stem cell gene expression programs influence clinical outcome in human leukemia Nature Medicine. ,vol. 17, pp. 1086- 1093 ,(2011) , 10.1038/NM.2415
Tim C.P. Somervaille, Christina J. Matheny, Gary J. Spencer, Masayuki Iwasaki, John L. Rinn, Daniela M. Witten, Howard Y. Chang, Sheila A. Shurtleff, James R. Downing, Michael L. Cleary, Hierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program Shared with Embryonic Rather Than Adult Stem Cells Cell Stem Cell. ,vol. 4, pp. 129- 140 ,(2009) , 10.1016/J.STEM.2008.11.015
Liqing Jin, Kristin J Hope, Qiongli Zhai, Florence Smadja-Joffe, John E Dick, Targeting of CD44 eradicates human acute myeloid leukemic stem cells Nature Medicine. ,vol. 12, pp. 1167- 1174 ,(2006) , 10.1038/NM1483
Shinsuke Ito, Ana C. D’Alessio, Olena V. Taranova, Kwonho Hong, Lawrence C. Sowers, Yi Zhang, Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Nature. ,vol. 466, pp. 1129- 1133 ,(2010) , 10.1038/NATURE09303
Matilde Todaro, Miriam Gaggianesi, Veronica Catalano, Antonina Benfante, Flora Iovino, Mauro Biffoni, Tiziana Apuzzo, Isabella Sperduti, Silvia Volpe, Gianfranco Cocorullo, Gaspare Gulotta, Francesco Dieli, Ruggero De Maria, Giorgio Stassi, CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis Cell Stem Cell. ,vol. 14, pp. 342- 356 ,(2014) , 10.1016/J.STEM.2014.01.009
David Naor, Shulamit B. Wallach-Dayan, Muayad A. Zahalka, Ronit Vogt Sionov, Involvement of CD44, a molecule with a thousand faces, in cancer dissemination. Seminars in Cancer Biology. ,vol. 18, pp. 260- 267 ,(2008) , 10.1016/J.SEMCANCER.2008.03.015
Alexander Pietras, Amanda M. Katz, Elin J. Ekström, Boyoung Wee, John J. Halliday, Kenneth L. Pitter, Jillian L. Werbeck, Nduka M. Amankulor, Jason T. Huse, Eric C. Holland, Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth Cell Stem Cell. ,vol. 14, pp. 357- 369 ,(2014) , 10.1016/J.STEM.2014.01.005