Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria
作者： Klaus Jung , Monika Pergande
DOI: 10.1016/0014-5793(85)80977-7
关键词:
摘要: In vitro exposure of isolated rat kidney mitochondria to cyclosporin A, a new immunosuppressive agent with serious nephrotoxic side-effects, leads alterations both succinate- and glutamate plus malate-supported respiration in dose-related manner. ADP- 2,4-dinitrophenol-stimulated respiration, respiratory control indices, ADP/O ratios are decreased. The mitochondrial discussed as possible pathogenetic reasons A nephrotoxicity.
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