TRPV channels as thermosensory receptors in epithelial cells.

摘要: Temperature-sensitive transient receptor potential vanilloid (TRPV) ion channels are critical contributors to normal pain and temperature sensation therefore represent attractive targets for therapy. When these were first discovered, most attention was focused on their contributions direct thermal activation of peripheral sensory neurons. However, recent anatomical, physiological, behavioral studies have provided evidence that TRPV expressed in skin epithelial cells may also contribute thermosensation vitro vivo. Here, we review speculate possible communication mechanisms from cutaneous