Nitrile oxides: a key intermediate in organic synthesis.

摘要: Nitrile oxides have an illustrious history, some even known back in the nineteenth century, fruitful development of generation and their utility synthetic principle has been achieved only recent years. The nitrile were considered as a versatile key intermediates acts efficient 1,3-dipole 1,3-dipolar cycloaddition reactions. with various dipolarophiles leads to formation wide range five membered heterocyclic compounds such isoxazoles, isoxazolines, oxadiazoles, oxadiazolines, dioxazolidines etc. An up date information about methodologies adopted for oxides, organic synthesis, stereochemistry products presented this review article.