Nanosized Drug Carriers for Oral Delivery of Anticancer Compounds and the Importance of the Chromatographic Techniques

摘要: Abstract Cancer is the primary leading cause of mortality in world. The key a successful cancer treatment depends on many important parameters, such as application route, anticancer compound, and dosage form. Among administration routes, oral most widely used method. However, molecules conventional forms limited due to major problem—low bioavailability. Nanoscale drug delivery systems can ensure improve bioavailability drugs. Determination chemotherapeutically active from developed nanoscale has an role effectiveness nanoparticles. Chromatographic techniques, especially liquid chromatography, are very suitable accurate ways determine content pharmaceutical ingredient its stability both vitro vivo systems. This chapter describes importance lipid- polymer-based technologies summarizes effect type nanostructures, characterization analysis column types mobile phase compositions, validation parameters.