Immune evasion by Mycobacterium tuberculosis: living with the enemy

摘要: Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an immunocompetent host. This bacterium lives within the macrophage, cell whose function elimination microbes. Recent advances have improved our understanding how M. evades two major antimicrobial mechanisms macrophages: phagolysosome fusion and production toxic reactive nitrogen intermediates. also modulates antigen presentation prevent detection infected macrophages by CD4+ T cells.